解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Baculoviruses are well known for their potential as biological agents for controlling agricultural and forest pests. They are also widely used as expression vectors in molecular cloning studies. The genome sequences of 48 baculoviruses are currently available in NCBI databases. As the number of sequenced vir...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-91
更新日期:2009-02-25 00:00:00
abstract:BACKGROUND:A major goal of post-genomics research is the integrated analysis of genes, regulatory elements and the chromatin architecture on a genome-wide scale. Mapping DNase I hypersensitive sites within the nuclear chromatin is a powerful and well-established method of identifying regulatory element candidates. RES...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-92
更新日期:2009-02-25 00:00:00
abstract:BACKGROUND:Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines oncogenic phenotype, is a transcriptional regulator and dysregulat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-67
更新日期:2009-02-06 00:00:00
abstract:BACKGROUND:Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland. Comparative analysis of the complete genome sequence of S. uberis strain...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-54
更新日期:2009-01-28 00:00:00
abstract:BACKGROUND:The origin and importance of exon-intron architecture comprises one of the remaining mysteries of gene evolution. Several studies have investigated the variations of intron length, GC content, ordinal position in a gene and divergence. However, there is little study about the structural variation of exons an...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-47
更新日期:2009-01-24 00:00:00
abstract:BACKGROUND:Co-expressing genes tend to cluster in eukaryotic genomes. This paper analyzes correlation between the proximity of eukaryotic genes and their transcriptional expression pattern in the zebrafish (Danio rerio) genome using available microarray data and gene annotation. RESULTS:The analyses show that neighbou...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-42
更新日期:2009-01-22 00:00:00
abstract:BACKGROUND:Biologists need to perform complex queries, often across a variety of databases. Typically, each data resource provides an advanced query interface, each of which must be learnt by the biologist before they can begin to query them. Frequently, more than one data source is required and for high-throughput ana...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-22
更新日期:2009-01-14 00:00:00
abstract:BACKGROUND:Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the present functions of...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-17
更新日期:2009-01-12 00:00:00
abstract:BACKGROUND:Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-637
更新日期:2008-12-31 00:00:00
abstract:BACKGROUND:Skeletal muscle mass can be markedly reduced through a process called atrophy, as a consequence of many diseases or critical physiological and environmental situations. Atrophy is characterised by loss of contractile proteins and reduction of fiber volume. Although in the last decade the molecular aspects un...
journal_title:BMC genomics
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2164-9-630
更新日期:2008-12-23 00:00:00
abstract:BACKGROUND:High Density Oligonucleotide arrays (HDONAs), such as the Affymetrix HG-U133A GeneChip, use sets of probes chosen to match specified genes, with the expectation that if a particular gene is highly expressed then all the probes in that gene's probe set will provide a consistent message signifying the gene's p...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-613
更新日期:2008-12-18 00:00:00
abstract:BACKGROUND:High throughput genotyping of single nucleotide polymorphisms (SNPs) for genome-wide association requires technologies for generating millions of genotypes with relative ease but also at a reasonable cost and with high accuracy. In this work, we have developed a theoretical approach to estimate allele freque...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-605
更新日期:2008-12-16 00:00:00
abstract:BACKGROUND:Streptococcus agalactiae (group B Streptococcus; GBS) is a significant bacterial pathogen of neonates and an emerging pathogen of adults. Though transcriptional regulators are abundantly encoded on the GBS genome, their role in GBS pathogenesis is poorly understood. The mtaR gene encodes a putative LysR-type...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-607
更新日期:2008-12-16 00:00:00
abstract:BACKGROUND:Candida albicans is a diploid pathogenic fungus not yet amenable to routine genetic investigations. Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing microbial agent. RES...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-578
更新日期:2008-12-02 00:00:00
abstract:BACKGROUND:The technological evolution of platforms for detecting genome-wide copy number imbalances has allowed the discovery of an unexpected amount of human sequence that is variable in copy number among individuals. This type of human variation can make an important contribution to human diversity and disease susce...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-573
更新日期:2008-11-28 00:00:00
abstract:BACKGROUND:Fluorescence of dyes bound to double-stranded PCR products has been utilized extensively in various real-time quantitative PCR applications, including post-amplification dissociation curve analysis, or differentiation of amplicon length or sequence composition. Despite the current era of whole-genome sequenc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-544
更新日期:2008-11-17 00:00:00
abstract:BACKGROUND:While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus performed full genome analyses on four Listeria monocytogenes, including human and food isolates from both a 1988 case of sporadic...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-539
更新日期:2008-11-13 00:00:00
abstract:BACKGROUND:This paper presents a retrospective statistical study on the newly-released data set by the Stanley Neuropathology Consortium on gene expression in bipolar disorder and schizophrenia. This data set contains gene expression data as well as limited demographic and clinical data for each subject. Previous studi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-531
更新日期:2008-11-07 00:00:00
abstract:BACKGROUND:Protein-protein interaction (PPI) maps are useful tools for investigating the cellular functions of genes. Thus far, large-scale PPI mapping projects have not been implemented for the rice blast fungus Magnaporthe grisea, which is responsible for the most severe rice disease. Inspired by recent advances in P...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-519
更新日期:2008-11-02 00:00:00
abstract:BACKGROUND:Identifying the set of intrinsically conserved genes, or the genomic core, among related genomes is crucial for understanding prokaryotic genomes where horizontal gene transfers are common. Although core genome identification appears to be obvious among very closely related genomes, it becomes more difficult...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-515
更新日期:2008-10-31 00:00:00
abstract:BACKGROUND:By assaying hundreds of thousands of single nucleotide polymorphisms, genome wide association studies (GWAS) allow for a powerful, unbiased review of the entire genome to localize common genetic variants that influence health and disease. Although it is widely recognized that some correction for multiple tes...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-516
更新日期:2008-10-31 00:00:00
abstract:BACKGROUND:Genomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties of those genomes. RESULTS:We have analyzed aspects of the information content of Homo sapiens, Mus musculus, Drosophila melanogast...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-509
更新日期:2008-10-30 00:00:00
abstract:BACKGROUND:The Spemann/Mangold organizer is a transient tissue critical for patterning the gastrula stage vertebrate embryo and formation of the three germ layers. Despite its important role during development, there are still relatively few genes with specific expression in the organizer and its derivatives. Foxa2 is ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-511
更新日期:2008-10-30 00:00:00
abstract:BACKGROUND:Very little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize gene expression responses of axolotls (Ambystoma mexicanum) to an emerging viral pathogen, Ambystoma tigrinum virus (ATV). RESU...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-493
更新日期:2008-10-20 00:00:00
abstract:BACKGROUND:Nonspecific hybridization is currently a major concern with microarray technology. One of most effective approaches to estimating nonspecific hybridizations in oligonucleotide microarrays is the utilization of mismatch probes; however, this approach has not been used for longer oligonucleotide probes. RESUL...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-491
更新日期:2008-10-17 00:00:00
abstract:BACKGROUND:Alternative synonymous codons are not used with equal frequencies. In addition, the contexts of codons - neighboring nucleotides and neighboring codons - can have certain patterns. The codon context can influence both translational accuracy and elongation rates. However, it is not known how strong or conserv...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-463
更新日期:2008-10-08 00:00:00
abstract:BACKGROUND:Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic patho...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-449
更新日期:2008-09-30 00:00:00
abstract:BACKGROUND:Hop (Humulus lupulus L.) is an economically important plant forming organogenic nodules which can be used for genetic transformation and micropropagation. We are interested in the mechanisms underlying reprogramming of cells through stress and hormone treatments. RESULTS:An integrated molecular and metabolo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-445
更新日期:2008-09-29 00:00:00
abstract:BACKGROUND:Ubiquitination is an important post-translational modification involved in diverse biological processes. Therefore, genomewide representation of the ubiquitination system for a species is important. DESCRIPTION:SCUD is a web-based database for the ubiquitination system in Saccharomyces cerevisiae (Baker's y...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-440
更新日期:2008-09-24 00:00:00
abstract:BACKGROUND:Because of the advent of high-throughput sequencing and the consequent reduction in the cost of sequencing, many organisms have been completely sequenced and most of their genes identified. It thus has become possible to represent whole genomes as ordered lists of gene identifiers and to study the rearrangem...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S2-S15
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:Dimension reduction is a critical issue in the analysis of microarray data, because the high dimensionality of gene expression microarray data set hurts generalization performance of classifiers. It consists of two types of methods, i.e. feature selection and feature extraction. Principle component analysis ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S2-S24
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors upon radiotherapy decrease according to the sizes of tumors and RT models based on Poisson statistics ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-S2-S9
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:A fundamental requirement for genomic studies is the availability of genetic material of good quality and quantity. The desired quantity and quality are often hard to obtain when target DNA is composed of complex mixtures of relatively short DNA fragments. Here, we sought to develop a method to representativ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-415
更新日期:2008-09-15 00:00:00
abstract:BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid x receptor alpha (RXRalpha) are involved in hepatocellular carcinogenesis. The phenotype of hepatocyte RXRalpha deficient mice is different between genders. To...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-403
更新日期:2008-08-28 00:00:00
abstract:BACKGROUND:Much of the morphological diversity in eukaryotes results from differential regulation of gene expression in which transcription factors (TFs) play a central role. The nematode Caenorhabditis elegans is an established model organism for the study of the roles of TFs in controlling the spatiotemporal pattern ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-399
更新日期:2008-08-27 00:00:00
abstract:BACKGROUND:Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G protein-coupled receptors to stimulate the proliferation, migration and survival of many cell types. LPA signaling has been implicated in development, wound healing and cancer. While LPA signaling pathways have been studied extensiv...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-387
更新日期:2008-08-14 00:00:00
abstract:BACKGROUND:The Zap1 transcription factor is a central player in the response of yeast to changes in zinc status. We previously used transcriptome profiling with DNA microarrays to identify 46 potential Zap1 target genes in the yeast genome. In this new study, we used complementary methods to identify additional Zap1 ta...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-370
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:We previously described the first respiratory Saccharomyces cerevisiae strain, KOY.TM6*P, by integrating the gene encoding a chimeric hexose transporter, Tm6*, into the genome of an hxt null yeast. Subsequently we transferred this respiratory phenotype in the presence of up to 50 g/L glucose to a yeast strai...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-365
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo at the transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal (IC40) concentrations of the drug to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-358
更新日期:2008-07-30 00:00:00
abstract:BACKGROUND:Human interfollicular epidermis is sustained by the proliferation of stem cells and their progeny, transient amplifying cells. Molecular characterization of these two cell populations is essential for better understanding of self renewal, differentiation and mechanisms of skin pathogenesis. The purpose of th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-359
更新日期:2008-07-30 00:00:00